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If concomitant use is warranted, carefully observe the patient, particularly during treatment initiation and dose adjustment. Discontinue Demerol Injection if serotonin syndrome is suspected. To prevent constipation, eat a diet adequate in fiber, drink plenty of water, and exercise. If you become constipated while using this drug, consult your pharmacist for help in selecting a laxative such as a stimulant-type with stool softener. This information should not be used to decide whether or not to take Detrol LA extended-release capsules or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about Detrol LA extended-release capsules. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to Detrol LA extended-release capsules. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using Detrol LA extended-release capsules.

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Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose. Drink plenty of water: You should drink at least 64 ounces of water each day. Some of that liquid can be orange juice, lemonade, or limeade. Acute overdose with Demerol Injection can be manifested by respiratory depression, somnolence progressing to stupor or coma, skeletal muscle flaccidity, cold and clammy skin, constricted pupils, and, in some cases, pulmonary edema, bradycardia, hypotension, partial or complete airway obstruction, atypical snoring, and death.

Consult your pharmacist for further advice

If concomitant use of acyclovir and Demerol Injection is necessary, monitor patients for respiratory depression and sedation at frequent intervals. WebMD User Reviews should not be considered as medical advice and are not a substitute for professional medical advice, diagnosis, or treatment. Never delay or disregard seeking professional medical advice from your physician or other qualified healthcare provider because of something you have read on WebMD. You should always speak with your doctor before you start, stop, or change any prescribed part of your care plan or treatment. WebMD understands that reading individual, real-life experiences may be a helpful health information resource but they are never a substitute for professional medical advice from a qualified healthcare provider.

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It is unknown if this drug passes into breast milk. Consult your doctor before breast-feeding. Pfizer also has programs that provide eligible patients with insurance support, copay assistance, and medicines for free. Taking flecainide with other agents that can affect your heart rhythm may increase your risk of an irregular heartbeat, which may be life-threatening.



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If concomitant use is necessary, consider increasing the Demerol Injection dosage until stable drug effects are achieved. Monitor for signs of opioid withdrawal. If a CYP3A4 or CYP2B6 inducer is discontinued, consider Demerol Injection dosage reduction and monitor for signs of respiratory depression. Monitor these patients for signs of hypotension after initiating or titrating the dosage of Demerol Injection. In patients with circulatory shock, Demerol Injection may cause vasodilation that can further reduce cardiac output and blood pressure. Avoid the use of Demerol Injection in patients with circulatory shock. Some MEDICINES MAY INTERACT with Detrol LA extended-release capsules. Take this by with or without food as directed by your doctor, usually once or twice daily. This means you may dribble urine. Inadvertent injection about a nerve trunk may result in sensory-motor paralysis which is usually, though not always, transitory. All patients treated with opioids require careful monitoring for signs of abuse and addiction, since use of opioid analgesic products carries the risk of addiction even under appropriate medical use. Due to additive pharmacologic effect, the concomitant use of benzodiazepines or other CNS depressants, including alcohol, can increase the risk of hypotension respiratory depression, profound sedation, coma, and death. Respiratory depression is the chief risk for elderly patients treated with opioids, and has occurred after large initial doses were administered to patients who were not opioid-tolerant or when opioids were co-administered with other agents that depress respiration. Opioids can reduce the efficacy of diuretics by inducing the release of antidiuretic hormone.



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Medications, electrical stimulation, or surgery. Doctors sometimes prescribe medicines that block the of an overactive bladder. Electrical stimulation of the bladder nerves helps in some cases. Surgery is reserved for severe cases. It aims to increase the amount of urine your bladder can store. Drinking alcohol can increase some of the side effects of tolterodine. There is a relationship between increasing meperidine plasma concentration and increasing frequency of dose-related opioid adverse reactions such as nausea, vomiting, CNS effects, and respiratory depression. Drug-seeking" behavior is very common in persons with substance use disorders. Drug-seeking tactics include emergency calls or visits near the end of office hours, refusal to undergo appropriate examination, testing, or referral, repeated "loss" of prescriptions, tampering with prescriptions, and reluctance to provide prior medical records or contact information for other treating health care providers. "Doctor shopping" visiting multiple prescribers to obtain additional prescriptions is common among drug abusers and people suffering from untreated addiction. Preoccupation with achieving adequate pain relief can be appropriate behavior in a patient with poor pain control. What should I avoid while taking tolterodine Detrol? This may not be a complete list of all interactions that may occur. Ask your health care provider if Detrol LA extended-release capsules may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine. Serious, life-threatening, or fatal respiratory depression may occur with use of Demerol Injection. Do 3 or 4 sets daily. Serotonin syndrome: Cases of serotonin syndrome, a potentially life-threatening condition, have been reported during concomitant use of opioids with serotonergic drugs. Demerol Injection exposes patients and other users to the risks of opioid addiction, abuse, and misuse, which can lead to overdose and death. If your kidney stone is small, you may be able to get rid of it when you pee. imuran



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QTdrugs List, AZCERT, Inc. If there's a blockage, you may need surgery. Tolterodine may also be used for purposes not listed in this medication guide. Moderate. These medicines may cause some risk when taken together. Cases of serotonin syndrome, a potentially life-threatening condition, have been reported during concomitant use of Demerol Injection with serotonergic drugs. Studies in animals to evaluate the mutagenic potential of meperidine have not been conducted. But they are created when your has high levels of certain minerals. What happens if I overdose Detrol LA? Talk to your doctor about using tolterodine safely. Do not crush, chew, break, or open a controlled-release capsule. Swallow it whole. Breaking or opening the pill may cause too much of the drug to be released at one time. Use this medication regularly to get the most benefit from it. To help you remember, take it at the same times each day. It is important to continue taking this medication even if you feel well. Most people with not feel sick. Methylprednisolone may make you dizzy. not drive, use machinery, or do any activity that requires alertness until you are sure you can perform such activities safely. What happens if I overdose Detrol? With this type, urine leaks due to weakened pelvic floor muscles and tissues. spod.info estrace



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Because of these risks, reserve concomitant prescribing of these drugs for use in patients for whom alternative treatment options are inadequate. RxList is part of the WebMD Health Network. The opinions expressed in the WebMD User Reviews are solely those of the User, who may or may not have medical or scientific training, and do not represent the opinions of WebMD. These member reviews have not been reviewed by a WebMD physician or any member of the WebMD editorial staff for accuracy, balance, objectivity, or any other purpose except for compliance with our Terms and Conditions. See "What Are Side Effects Associated with Using Tolterodine? Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company. Serious, life-threatening, or fatal respiratory depression has been reported with the use of opioids, even when used as recommended. Respiratory depression, if not immediately recognized and treated, may lead to respiratory arrest and death. This drug may make you dizzy. not drive, use machinery, or do any activity that requires alertness until you are sure you can perform such activities safely. Limit beverages. Do not use Demerol Injection in patients taking MAOIs or within 14 days of stopping such treatment. Store at room temperature away from moisture and heat. The most frequently observed adverse reactions include lightheadedness, dizziness, sedation, nausea, vomiting, and sweating. These effects seem to be more prominent in ambulatory patients and in those who are not experiencing severe pain. In such individuals, lower doses are advisable. Some adverse reactions in ambulatory patients may be alleviated if the patient lies down. Prescription drug abuse is the intentional non-therapeutic use of a prescription drug, even once, for its rewarding psychological or physiological effects. If any of these effects persist or worsen, tell your doctor or pharmacist promptly. What is tolterodine Detrol?



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Gastrointestinal. Dry mouth, constipation, biliary tract spasm. Prolonged use of Demerol Injection during pregnancy can result in neonatal opioid withdrawal syndrome, which may be life-threatening if not recognized and treated, and requires management according to protocols developed by neonatology experts. The opioid antagonists, naloxone or nalmefene, are specific antidotes to respiratory depression resulting from opioid overdose. For clinically significant respiratory or circulatory depression secondary to meperidine overdose, administer an opioid antagonist. Opioid antagonists should not be administered in the absence of clinically significant respiratory or circulatory depression secondary to meperidine overdose. Intravenous hydrocortisone or prednisolone have been used to treat severe reactions, with the addition of intravenous chlorpromazine in those cases exhibiting hypertension and hyperpyrexia. The usefulness and safety of narcotic antagonists in the treatment of these reactions is unknown. If the level of pain increases after dosage stabilization, attempt to identify the source of increased pain before increasing the Demerol Injection dosage. If unacceptable opioid-related adverse reactions are observed, consider reducing the dosage. Adjust the dosage to obtain an appropriate balance between management of pain and opioid-related adverse reactions. store actonel uses



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Tell your doctor if your condition does not improve or if it worsens. When a patient who has been taking Demerol Injection regularly and may be physically dependent no longer requires therapy with Demerol Injection, taper the dose gradually, by 25% to 50% every 2 to 4 days, while monitoring carefully for signs and symptoms of withdrawal. If the patient develops these signs or symptoms, raise the dose to the previous level and taper more slowly, either by increasing the interval between decreases, decreasing the amount of change in dose, or both. For certain products of this drug, an empty tablet shell may appear in your stool. This is harmless. It is readily soluble in water and has a neutral reaction and a slightly bitter taste. The solution is not decomposed by a short period of boiling. There are many other drugs that can interact with tolterodine. Tell your doctor about all medications you use. This includes prescription, over the counter, vitamin, and herbal products. Do not start a new medication without telling your doctor. Keep a list of all your medicines and show it to any healthcare provider who treats you. Advise both patients and caregivers about the risks of respiratory depression and sedation when Demerol Injection is used with benzodiazepines or other CNS depressants including alcohol and illicit drugs. Advise patients not to drive or operate heavy machinery until the effects of concomitant use of the benzodiazepine or other CNS depressant have been determined. flutamide share price yahoo



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This medication contains tolterodine. Do not take Detrol or Detrol LA if you are allergic to tolterodine or any ingredients contained in this drug. Neonatal opioid withdrawal syndrome presents as irritability, hyperactivity and abnormal sleep pattern, high pitched cry, tremor, vomiting, diarrhea, and failure to gain weight. The onset, duration, and severity of neonatal opioid withdrawal syndrome vary based on the specific opioid used, duration of use, timing and amount of last maternal use, and rate of elimination of the drug by the newborn. Monitor for signs of opioid withdrawal. Carpuject are packaged in a Slim-Pak tamper detection package. Note that a needle is not included. Meperidine, in 60 mg to 80 mg parenteral doses, is approximately equivalent in analgesic effect to 10 mg of morphine. The onset of action is slightly more rapid than with morphine, and the duration of action is slightly shorter. Meperidine is significantly less effective by the oral than by the parenteral route, but the exact ratio of oral to parenteral effectiveness is unknown. Side Effects List Detrol LA side effects by likelihood and severity. If any of these effects persist or worsen, tell your doctor or promptly. Meperidine produces respiratory depression by direct action on brain stem respiratory centers. The respiratory depression involves a reduction in the responsiveness of the brain stem respiratory centers to both increases in carbon dioxide tension and electrical stimulation. Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication not have serious side effects. The following adverse reactions associated with the use of meperidine were identified in clinical studies or postmarketing reports. Because some of these reactions were reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure. Warning: The facts and figures contained in these reports are accurate to the best of our capability; however, our metrics are only meant to augment your medical knowledge, and should never be used as the sole basis for selecting a new medication. As with any medical decision, be sure to work with your doctor to ensure the best choices are made for your condition. If concomitant use cimetidine and Demerol Injection is necessary, monitor patients for respiratory depression and sedation at frequent intervals. What happens if I miss a dose Detrol? Swallow Detrol LA extended-release capsules whole. Do not break, crush, or chew before swallowing. Inform your doctor if your condition persists or worsens.



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If any of these effects persist or worsen, notify your doctor or promptly. Tell your doctor or pharmacist if you are taking other products that cause drowsiness including alcohol, antihistamines such as cetirizine, diphenhydramine drugs for sleep or anxiety such as alprazolam, diazepam, zolpidem muscle relaxants, and narcotic pain relievers such as codeine. Do not start, stop, or change the dosage of any medicines without your doctor's approval. Many drugs besides tolterodine may affect the heart rhythm QT prolongation including amiodarone, dofetilide, pimozide, procainamide, quinidine, sotalol, macrolide antibiotics such as erythromycin among others. Assess each patient's risk for opioid addiction, abuse, or misuse prior to prescribing Demerol Injection, and monitor all patients receiving Demerol Injection for the development of these behaviors and conditions. Mental or physical problems such as or prevent you from getting to the bathroom in time. Demerol Injection contains meperidine, a substance with a high potential for abuse similar to other opioids including fentanyl, hydrocodone, hydromorphone, methadone, morphine, oxycodone, oxymorphone, and tapentadol. What is the most important information I should know about tolterodine Detrol LA? Remember that your doctor has prescribed this because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication not have serious side effects. Before you take tolterodine, tell your doctor if you have kidney or liver disease, glaucoma, myasthenia gravis, or a personal or family history of "Long QT syndrome. You should not take this medication if you are allergic to tolterodine or fesoterodine Toviaz if you have untreated or uncontrolled narrow-angle glaucoma, or if you have a blockage of the urinary tract, stomach, or intestines. buy priligy otc online



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Meperidine appears in the milk of nursing mothers receiving the drug. The developmental and health benefits of breastfeeding should be considered along with the mother's clinical need for Demerol Injection and any potential adverse effects on the breastfed infant from Demerol Injection or from the underlying maternal condition. Do NOT change your dose of Detrol LA extended-release capsules without checking with your doctor. For these reasons, FAERS case reports cannot be used to calculate incidence or estimates of risk for a particular product or compare risks between products. Ask your health care provider any questions you may have about how to use Detrol LA extended-release capsules. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist. DEMEROL meperidine hydrochloride, USP Injection is an opioid agonist, available for intramuscular, intravenous, or subcutaneous administration. Meperidine hydrochloride is an opioid agonist with multiple actions qualitatively similar to those of morphine; the most prominent of these involve the central nervous system and organs composed of smooth muscle. The principal actions of therapeutic value are analgesia and sedation. DEMEROL is not a trademark of Hospira. While many dieters swear by high-, eating large amounts of can also cause a stone to form. Demerol Injection contains meperidine, a Schedule II controlled substance. This program provides uninsured patients with savings on their prescriptions at the pharmacy. dicyclomine how to buy store



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If you miss a dose of Detrol LA extended-release capsules, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once. The dose should be titrated to the needs of the patient and will depend on the premedication and type of anesthesia being employed, the characteristics of the particular patient, and the nature and duration of the operative procedure. Elderly patients should usually be given meperidine at the lower end of the dose range and observed closely. Use Detrol LA extended-release capsules as directed by your doctor. Check the label on the medicine for exact dosing instructions. Butorphanol, nalbuphine, pentazocine, buprenorphine. Demerol Injection is contraindicated in patients with known or suspected gastrointestinal obstruction, including paralytic ileus. Pfizer also has programs that provide eligible patients with insurance, support assistance, and medicines at a savings. Contact Pfizer RxPathways for details 844-989-7284. In severe overdose, particularly by the intravenous route, apnea, circulatory collapse, cardiac arrest, and death may occur. Elderly patients aged 65 years or older may have increased sensitivity to meperidine. In general, use caution when selecting a dosage for an elderly patient, usually starting at the low end of the dosing range, reflecting the greater frequency of decreased hepatic, renal, or cardiac function and of concomitant disease or other drug therapy. These help to strengthen the pelvic floor after childbirth. They also help prevent stress incontinence. Best of all, you can do Kegels anytime, anywhere. Adults: The usual dosage is 50 mg to 100 mg intramuscularly or subcutaneously, 30 to 90 minutes before the beginning of anesthesia. Elderly patients should usually be given meperidine at the lower end of the dose range and observed closely. Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects. In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345. If a CYP3A4 or CYP2B6 inhibitor is discontinued, consider increasing the Demerol Injection dosage until stable drug effects are achieved. This may occur within the recommended dosage range. This medication may lower your ability to fight infections. This may make you more likely to get a serious rarely fatal infection or make any infection you have worse. Your pharmacist can provide more information about tolterodine.



What happens if I overdose Detrol LA?

If you do not take the same dose each day or if you take this medication every other day, ask your doctor or what you should do if you miss a dose. To reduce the risk of dizziness and lightheadedness, get up slowly when rising from a sitting or lying position. This means you have any two types of the condition. Many women have both stress and urge incontinence. Physical dependence results in withdrawal symptoms after abrupt discontinuation or a significant dosage reduction of a drug. Do not use Demerol Injection in patients taking MAOIs or within 14 days of stopping such treatment. Intravenous hydrocortisone or prednisolone have been used to treat severe reactions, with the addition of intravenous chlorpromazine in those cases exhibiting hypertension and hyperpyrexia. The usefulness and safety of narcotic antagonists in the treatment of these reactions is unknown. This is a long-acting form of that is used to treat and urinary conditions. Drowsiness and confusion can increase the risk of falling. Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Read the Patient Information Leaflet if available from your before you start taking and each time you get a refill. If you have any questions, ask your doctor or pharmacist. How should I take tolterodine Detrol? Squeeze the muscles that you use stop the flow of urine. The concomitant use of Demerol Injection with all cytochrome P450 3A4 inhibitors may result in an increase in meperidine plasma concentrations, which could increase or prolong adverse reactions and may cause potentially fatal respiratory depression. In addition, discontinuation of a concomitantly used cytochrome P450 3A4 inducer may result in an increase in meperidine plasma concentration. Detrol LA extended-release capsules may cause drowsiness, dizziness, or blurred vision. These effects may be worse if you take it with alcohol or certain medicines. Use Detrol LA extended-release capsules with caution. ramipril



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This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment. Blurred vision; constipation; dizziness; drowsiness; dry eyes; dry mouth; headache; indigestion; stomach pain. Prolonged use of opioid analgesics during pregnancy for medical or nonmedical purposes can result in physical dependence in the neonate and neonatal opioid withdrawal syndrome shortly after birth. The meperidine in Demerol Injection may increase the frequency of seizures in patients with seizure disorders, and may increase the risk of seizures occurring in other clinical settings associated with seizures. Monitor patients with a history of seizure disorders for worsened seizure control during Demerol Injection therapy. Demerol Injection may reduce respiratory drive, and the resultant CO 2 retention can further increase intracranial pressure. Monitor such patients for signs of sedation and respiratory depression, particularly when initiating therapy with Demerol Injection. While serious, life-threatening, or fatal respiratory depression can occur at any time during the use of Demerol Injection, the risk is greatest during the initiation of therapy or following a dosage increase. Monitor patients closely for respiratory depression, especially within the first 24 to 72 hours of initiating therapy with and following dosage increases of Demerol Injection. Studies to determine the effect of meperidine on fertility have not been conducted. Long-term studies in animals to evaluate the carcinogenic potential of meperidine have not been conducted. Prolonged use of Demerol Injection during pregnancy can result in withdrawal in the neonate. Neonatal opioid withdrawal syndrome, unlike opioid withdrawal syndrome in adults, may be life-threatening if not recognized and treated, and requires management according to protocols developed by neonatology experts. Observe newborns for signs of neonatal opioid withdrawal syndrome and manage accordingly. Opioids have been shown to have a variety of effects on components of the immune system in in vitro and animal models. The clinical significance of these findings is unknown. Overall, the effects of opioids appear to be modestly immunosuppressive. Kathleen Zelman, MPH, RD, Director of Nutrition, WebMD. carafate



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Shock wave lithotripsy: This is the most common procedure for kidney stones in the United States. It uses shock waves, which can blast the stone into little pieces. Then, the smaller pieces can more easily be passed in your urine. UpToDate: "Nutrition and Dietary Interventions in Adults with Inflammatory Bowel Disease. Marked mydriasis rather than miosis may be seen due to hypoxia in overdose situations.

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Elevated serum levels have been reported to cause central nervous system excitatory effects. Meperidine should therefore be used with caution in patients with hepatic impairment. Titrate the dosage of Demerol Injection slowly in patients with hepatic impairment and monitor closely for signs of central nervous system and respiratory depression. To prevent needle-stick injuries, needles should not be recapped, purposely bent, or broken by hand. The safety and effectiveness of meperidine in pediatric patients has not been established. Literature reports indicate that meperidine has a slower elimination rate in neonates and young infants compared to older children and adults. Neonates and young infants may also be more susceptible to the effects, especially the respiratory depressant effects. If meperidine use is contemplated in neonates or young infants, any potential benefits of the drug need to be weighed against the relative risk of the patient.

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All of these results will help the doctor figure out how best to treat you. Food and Drug Administration. WebMD does not endorse any specific product, service or treatment. Demerol Injection, like other opioids, can be diverted for non-medical use into illicit channels of distribution. Careful record-keeping of prescribing information, including quantity, frequency, and renewal requests, as required by state and federal law, is strongly advised.

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Flecainide can affect your heart's rhythm. Other drugs can have the same effect. In an individual physically dependent on opioids, administration of the recommended usual dosage of the antagonist will precipitate an acute withdrawal syndrome. The severity of the withdrawal symptoms experienced will depend on the degree of physical dependence and the dose of the antagonist administered. If a decision is made to treat serious respiratory depression in the physically dependent patient, administration of the antagonist should be begun with care and by titration with smaller than usual doses of the antagonist.

In case of overdose, priorities are the reestablishment of a patent and protected airway and institution of assisted or controlled ventilation, if needed. Employ other supportive measures including oxygen and vasopressors in the management of circulatory shock and pulmonary edema as indicated. Cardiac arrest or arrhythmias will require advanced life-support techniques. About FAERS: The FDA Adverse Event Reporting System FAERS is used by FDA for activities such as looking for new safety concerns that might be related to a marketed product, evaluating a manufacturer's compliance to reporting regulations and responding to outside requests for information. Reporting of adverse events is a voluntary process, and not every report is sent to FDA and entered into FAERS.

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